Testosterone is lower in men with non-alcoholic fatty liver disease and alcohol-related cirrhosis and is associated with adverse clinical outcomes

R Apostolov; D Wong; E Low; K Vaz; J Spurio; T Worland; D Liu; RK Chan; P Gow; M Grossmann; M Sinclair

Journal article

Testosterone is lower in men with non-alcoholic fatty liver disease and alcohol-related cirrhosis and is associated with adverse clinical outcomes

R Apostolov, D Wong, E Low, K Vaz, J Spurio, T Worland, D Liu, RK Chan, P Gow, M Grossmann, M Sinclair

Scandinavian Journal of Gastroenterology | TAYLOR & FRANCIS LTD | Published : 2023

DOI: 10.1080/00365521.2023.2220857

Abstract

Background/aims: Low serum testosterone is common in cirrhotic men, but the impact of disease aetiology remains uncertain. This study compares serum total testosterone (TT) levels by disease aetiology and assesses its prognostic value. Methods: Single-centre retrospective study of cirrhotic men who had TT levels measured between 2002 and 2020. A cut-off of 12 nmol/L was used to define low TT and 230 pmol/L for calculated free testosterone (cFT). Linear and logistic regression used to adjust for variables known to affect testosterone levels and assess for an association between levels and outcomes. Results: Of 766 cirrhotic men, 33.3% had alcohol-related liver disease (ALD) and 11.9% had non-..

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University of Melbourne Researchers

Darren Wong Author

Paul Gow Author

Mathis Grossmann Author

Marie Sinclair Author

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Funding Acknowledgements

RA was supported by a National Health and Medical Research Council Postgraduate Fellowship (Grant number 1191028). MG was supported by a National Health and Medical Research Council Project Grant (Grant number 1099173). MS was supported by a National Health and Medical Research Council Early Career Fellowship (Grant number 1138374).